Diuretic | Medicinal Chemistry | Aqsa Murtaza
PHARMA BY AQSA MURTAZA (PharmD) Aim to help Pharmacy Students. We cover a wide range of topics, from Medicinal Chemistry, Pharmacology, and Drug Inte ractions to Medication Management and Disease State Management. Medicinal Chemistry DIURETICS Site of action of each Diuretic It acts on the nephron. There are four sites in the nephron where it can act: 1. Site I - Proximal Convoluted Tubule (PCT) 2. Site II - Ascending Loop Of Henle 3. Site III - Distal Convoluted Tubule (DCT) 4. Site IV - Collecting Duct Drugs acting on PCT inhibit carbonic anhydrase 1. Acetazolamide 2. Methazolamide Drugs acting on ascending loop of henle inhibit the co-transport system 1. Furosemide 2. Ethacrynic Acid Drugs acting on DCT inhibit Na+/Cl- cotransporter 1. Chlorothiazide 2. Hydrochlorothiazide Drugs acting on the collecting duct inhibit Na+ reabsorption and K+ excretion 1. Spironolactone 2. Triamterene Acetazolamide • Acetazolamide act on site I - PCT. • Drugs acting on site I are 5-...