Antineoplastic Drugs | Medicinal Chemistry | Dr. Aqsa Murtaza
PHARMA BY AQSA MURTAZA (PharmD) Aim to help Pharmacy Students. We cover a wide range of topics, from Medicinal Chemistry, Pharmacology, and Drug Interactions to Medication Management and Disease State Management. MEDICINAL CHEMISTRY “Medicinal Chemistry is the science that deals with the discovery and design of new therapeutic chemicals and their development into useful medicines.” ANTINEOPLASTIC DRUGS 5-Fluorouracil INDICATION Head and neck cancer Breast cancer Liver cancer Lung cancer PROPERTIES White crystalline powder Odorless Insoluble in chloroform Slightly soluble in alcohol Pyrimidine analog Contraindicated in Pregnancy and lactation IV and topical route of administration CBC and Renal/Hepatic function must be monitored MECHANISM OF ACTION 5- Fluorouracil inhibit the biosynthesis of DNA by interfering with the conversion of deoxyuridylic acid → thymidylic acid thus ↓se the thymidine level in the cell. Produce effect in the S-Phase of the cell cycle. Interact with Ci...