PHARMA BY Dr. Aqsa Murtaza

  PHARMA BY AQSA MURTAZA (PharmD) Aim to help Pharmacy Students. We cover a wide range of topics, from Medicinal Chemistry, Pharmacology, and Drug Inte ractions to Medication Management and Disease State Management. CORTISOL PROPERTIES Antiinflammatory hormone White crystalline powder Water insoluble and soluble in organic solvents Rapidly absorbed from GIT Can cross the placenta barrier Synthesized in Zona fasciculate and Zona reticularis cells INDICATION Allergy Immunosuppressants ADR Osteoporosis SAR Flouride ion in place of the hydroxyl group with methyl increases its activity. Activity decreases if the hydroxyl group is replaced with chlorine or bromine group. Unsaturation in ring A lead to an increase in the activity of the drug. Substitution of the hydroxy group in ring B leads to a decrease in the activity of the drug. Structure of Cortisol GLUCAGON Contain 29 amino acids Synthesized in Pancrease A large dose of it leads to the intestine relaxation Have ionotropic effects o...

     PHARMA BY AQSA MURTAZA (PharmD) Aim to help Pharmacy Students. We cover a wide range of topics, from Medicinal Chemistry, Pharmacology, and Drug Interactions to Medication Management and Disease State Management. MEDICINAL CHEMISTRY HORMONES Oxytocin Vasopressin Estrogen Progesterone Cortisol Glucagon Insulin Testosterone Aldosterone   HORMONES The endocrine system is made up of the endocrine glands that secrete hormones. Chemical messenger Work slowly, over time, and controls many functions in our body. Hormones are carried by the blood throughout the entire body and affect specific cells. Metabolism, growth, etc.     OXYTOCIN Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 “Quick Birth” Induce labor Has 9-Amino acids, bound with a disulfide bridge Molecular formula = C43H66N12O12S2 Release from Posterior Pituitary Gland Given parenterally. ADR Severe uterine contraction Water retention Nasal irritation CONTRAINDICATION Uterine rupture Smooth muscle contracti...